052 Localized increased in chemokines associated with itch in hidradenitis suppurativa

Hidradenitis Suppurativa (HS) is an autoinflammatory skin disease characterized by painful, pruritic nodules, abscesses and pus-draining tunnels in intertriginous skin. To better elucidate the immune response leading to localized activity HS skin, we compared cytokines from 15 lesional perilesional biopsies patients with Hurley Stage II III HS. Patients additionally filled out a qualitative questionnaire assessing range of symptoms environmental factors including pain, itch, sweat levels diet at time biopsy. Cytokine were assessed using bead-based, multi-analyte immunoassay system. The expression IP-10 (CXCL-10), IL-8, MIP-alpha (CCL-3), MIP-beta (CCL-4), GRO-alpha (CXCL-1), 1L-1ß eotaxin-1 (CCL-11) all found be significantly enhanced clinically normal Eotaxin-1 displayed 1.8 fold elevation as (p=0.0234 paired t-test). eosinophil chemoattractant, also atopic dermatitis, that plays critical role tissue inflammation may linked pathogenesis highly flares. Overall, our results indicate inflammatory markers lesions are those produced keratinocytes (1L-1ß, CCL-3), T-cell or B-cell activation sites (CXCL-10 CCL-4, respectively) regulate neutrophil chemoattraction (CXCL-1) which align previously reported marker known lesions. We further stratifying these patient-reported symptoms, treatment, develop greater insight into treatment strategies pathogenic processes underlying